A thymidylate kinase inhibitor (IC50 = 610 nM); selective for thymidylate kinase over thymidine kinase 1; reduces dTTP levels by 30-40% in p58-/- HCT116 cells; sensitizes a variety of cancer cell lines to doxorubicin; reduces tumor growth in a p53-/- HCT116 mouse xenograft model at 5 mg/kg three times per week for four weeks

YMU1 – 5 mg

Brand:
Cayman
CAS:
902589-96-2
Storage:
-20
UN-No:
- /

YMU1 is an inhibitor of thymidylate kinase (TMPK; IC50 = 610 nM).{36989} It is selective for thymidylate kinase over thymidine kinase 1. YMU1 (2 and 10 µM) reduces deoxythymidine triphosphate (dTTP) levels by 30-40% in p58-/- HCT116 cells without affecting dATP, dGTP, or dCTP levels. It also sensitizes a variety of cancer cell lines to doxorubicin (Item No. 15007), including p53+/+ and p53-/- HCT116, HT-29, SaoS2, MDA-MB-231, and MDA-MB-468 cells. YMU1 reduces tumor growth in a p53-/- HCT116 mouse xenograft model when administered at a dose of 5 mg/kg three times per week for four weeks.  

 

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Description

A thymidylate kinase inhibitor (IC50 = 610 nM); selective for thymidylate kinase over thymidine kinase 1; reduces dTTP levels by 30-40% in p58-/- HCT116 cells; sensitizes a variety of cancer cell lines to doxorubicin; reduces tumor growth in a p53-/- HCT116 mouse xenograft model at 5 mg/kg three times per week for four weeks

Formal name: 4-[2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetyl]-1-piperazinecarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 378.5

CAS: 902589-96-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Metabolism||Research Area|Cancer|Transcription Factors|p53

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