A synthetic flavonoid with anticancer and anti-angiogenic activity; inhibits proliferation of HepG2

LYG-202 – 1 mg

Brand:
Cayman
CAS:
1175077-25-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

LYG-202 is a synthetic flavonoid with anticancer and anti-angiogenic activities.{39094, 39095} It inhibits proliferation of HepG2, MCF-7, HeLa, BGC-823, MDA-MB-435, and HCT116 cancer cells in vitro (IC50s = 4.74-27.70 μM) via induction of apoptosis and dissipation of the mitochondrial membrane potential.{39094} LYG-202 reduces tumor growth in S180 sarcoma cell-inoculated mice. It also inhibits VEGF-stimulated human umbilical vein endothelial cells (HUVEC) cell migration and tube formation in vitro and decreases capillary sprouting in isolated rat aortic rings and the chicken chorioallantoic membrane (CAM) model of angiogenesis.{39095}  

 

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Description

A synthetic flavonoid with anticancer and anti-angiogenic activity; inhibits proliferation of HepG2, MCF-7, HeLa, BGC-823, MDA-MB-435, and HCT116 cancer cells in vitro (IC50s = 4.74-27.70 μM); reduces tumor growth in S180 sarcoma cell-inoculated mice; inhibits VEGF-stimulated HUVEC cell migration and tube formation in vitro; decreases capillary sprouting in isolated rat aortic rings and the CAM model of angiogenesis,

Formal name: 5-hydroxy-8-methoxy-7-[4-(4-methyl-1-piperazinyl)butoxy]-2-phenyl-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 438.5

CAS: 1175077-25-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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