A plant defense alkaloid; has antiproliferative activity against HeLa

Camalexin – 5 mg

Brand:
Cayman
CAS:
135531-86-1
Storage:
-20
UN-No:
Non-Hazardous - /

Camalexin is an alkaloid released by plants of the Brassicaceae family in response to pathogen infection.{35038} In addition to antimicrobial properties and a role in plant defense, camalexin exhibits antiproliferative activity in vitro against various cancer cell lines.{35039,35040,35041,35042} Camalexin is active against HeLa, Jurkat, MDA-MB-231, and CEM cancer cell lines (IC50s = 50.0, 46.2, 77.7, and 67.6 μM, respectively), but it is also toxic to primary human umbilical vein endothelial cells (HUVEC; (IC50 = 74.0 μM).{35040} Camalexin induces apoptosis in Jurkat cells by increasing reactive oxygen species (ROS) levels and activating caspase-8 and caspase-9.{35039} In human prostate cancer cell lines, camalexin (25 μM) is more active against aggressive lines and increases ROS levels and apoptosis via cathepsin D relocation from lysosomes to the cytosol.{35042,35043}  

 

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Description

A plant defense alkaloid; has antiproliferative activity against HeLa, Jurkat, MDA-MB-231, CEM, and HUVEC cell lines (IC50s = 50.0, 46.2, 77.7, 67.6, and 74.0 μmol/L, respectively); raises ROS, activates caspase-8 and caspase-9, relocates cathepsin D from lysosomes to cytosol

Formal name: 3-(2-thiazolyl)-1H-indole

Synonyms: 

Molecular weight: 200.3

CAS: 135531-86-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease||Research Area|Plant Biology|Plant Defense

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