A naphthoquinone with diverse biological activities; inhibits U-46619-induced rabbit platelet aggregation in vitro (IC50 = 0.58 μM); inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets; inhibits human platelet aggregation induced by ADP

NQ301 – 5 mg

Brand:
Cayman
CAS:
130089-98-4
Storage:
-20
UN-No:
Non-Hazardous - /

NQ301 is a naphthoquinone with diverse biological activities, including antiplatelet, antithrombotic, anti-inflammatory, and antimicrobial properties.{46244,46245,46246,46247} It inhibits rabbit platelet aggregation induced by the thromboxane A2 receptor agonist U-46619 (Item No. 16450) in vitro (IC50 = 0.58 μM) and inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets in a concentration-dependent manner.{46244} It also inhibits human platelet aggregation induced by ADP, collagen, epinephrine, and the calcium ionophore A23187 in vitro (IC50s = 3.21, 15.69, 8.44, and 44.2 μM, respectively).{46245} NQ301 (50 and 100 mg/kg) increases tail bleeding time and exhibits a protective effect against pulmonary thrombosis in mice. It inhibits the protein tyrosine phosphatase CD45 with an IC50 value of 0.29 μM.{46246} NQ301 (3 mg/kg) inhibits ovalbumin-induced footpad swelling in a mouse model of delayed-type hypersensitivity. It is also active against C. albicans, A. niger, B. subtilis, S. aureus, E. coli, and P. aeruginosa (MICs = 12.5-50 μg/ml).{46247}  

 

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Description

A naphthoquinone with diverse biological activities; inhibits U-46619-induced rabbit platelet aggregation in vitro (IC50 = 0.58 μM); inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets; inhibits human platelet aggregation induced by ADP, collagen, epinephrine, and A23187 in vitro (IC50s = 3.21, 15.69, 8.44, and 44.2 μM, respectively); increases tail bleeding time and exhibits a protective effect against pulmonary thrombosis in mice at 50 and 100 mg/kg; inhibits CD45 (IC50 = 0.29 μM); inhibits ovalbumin-induced footpad swelling in a mouse model of delayed-type hypersensitivity at 3 mg/kg; is active against C. albicans, A. niger, B. subtilis, S. aureus, E. coli, and P. aeruginosa (MICs = 12.5-50 μg/ml)

Formal name: 2-[(4-acetylphenyl)amino]-3-chloro-1,4-naphthalenedione

Synonyms: 

Molecular weight: 325.8

CAS: 130089-98-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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