A taurine-conjugated form of hyodeoxycholic acid; decreases the size and weight of human gallstones in vitro; prevents hepatotoxicity induced by TCDCA

Taurohyodeoxycholic Acid (sodium salt) – 1 mg

Brand:
Cayman
CAS:
38411-85-7
Storage:
-20
UN-No:
Non-Hazardous - /

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid (Item No. 20294).{39310} THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.{39309} Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; Item No. 20275) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.{39311} THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.{39312}  

 

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Description

A taurine-conjugated form of hyodeoxycholic acid; decreases the size and weight of human gallstones in vitro; prevents hepatotoxicity induced by TCDCA, increasing bile flow as well as biliary acid and phospholipid secretion in rats; reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis

Formal name: 2-[[(3α,5β,6α)-3,6-dihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt

Synonyms:  Taurine Hyodeoxycholate|THDCA

Molecular weight: 521.7

CAS: 38411-85-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Lipid Biochemistry

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