A TRPML1 activator (EC50s = 110

MK6-83 – 1 mg

Brand:
Cayman
CAS:
1062271-24-2
Storage:
-20
UN-No:
Non-Hazardous - /

MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1).{34609} TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts.{34609} It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.  

 

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Description

A TRPML1 activator (EC50s = 110, 100, and 1,230 nM in wild type, F465L, and F408Δ-expressing fibroblasts, respectively); improves zinc trafficking out of lysosomes

Formal name: 5-methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Synonyms: 

Molecular weight: 336.5

CAS: 1062271-24-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Neuroscience

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