A selective P2X7 antagonist; reduces BzATP-induced calcium influx in 1321N1 cells transfected with recombinant P2X7 human

JNJ-47965567 – 5 mg

Brand:
Cayman
CAS:
1428327-31-4
Storage:
-20
UN-No:
Non-Hazardous - /

JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel. Activation of P2X receptors by BzATP (Item No. 15577) induces calcium flux, which is reduced by JNJ-47965567 in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively.{34131} JNJ-47965567 suppresses neonatal hypoxia-induced seizures in mice and has some anticonvulsant properties in rats.{34134,34132} It also reduces spontaneous seizures in epileptic mice even after treatment is stopped.{34133}  

 

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Description

A selective P2X7 antagonist; reduces BzATP-induced calcium influx in 1321N1 cells transfected with recombinant P2X7 human, macaque, dog, rat, or mouse protein with pIC50s of 8.3, 8.6, 8.5, 7.2, or 7.5, respectively; has anticonvulsant properties

Formal name: 2-(phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide

Synonyms: 

Molecular weight: 488.6

CAS: 1428327-31-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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