An internal standard for the quantification of ursodeoxycholic acid by GC- or LC-MS

Ursodeoxycholic Acid-d4 – 5 mg

Brand:
Cayman
CAS:
347841-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item No. 10011286).{48224,48225} UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.{48226} It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.{24182} UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes.{48227} Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.  

 

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Description

An internal standard for the quantification of ursodeoxycholic acid by GC- or LC-MS,

Formal name: (3α,5β,7β)-3,7-dihydroxy-cholan-24-oic-2,2,4,4-d4 acid

Synonyms:  UDCA-d4

Molecular weight: 396.6

CAS: 347841-46-7

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Lipid Biochemistry|Lipid Transport

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