A inhibitor of endosomal trafficking; increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells at 20 μM; inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins

EGA – 1 mg

Brand:
Cayman
CAS:
415687-81-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

EGA is an inhibitor of endosomal trafficking.{46123} It increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells when used at a concentration of 20 μM. EGA inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and H. ducreyi cytolethal distending toxin (Hd-CDT), in various cell types. It also inhibits infection of Vero and HeLa cells by the low pH-dependent lymphocytic choriomeningitis (LCMV; Armstrong strain) and influenza A/WSN/33 viruses, respectively.  

 

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Description

A inhibitor of endosomal trafficking; increases accumulation of fluorescently labeled EGF in early endosomes in HeLa cells at 20 μM; inhibits cell death induced by anthrax lethal toxin in RAW264.7 cells (IC50 = 1.7 μM) as well as by additional acid-dependent bacterial toxins, including diphtheria toxin, P. aeruginosa ExoA, and Hd-CDT, in various cell types; inhibits infection of Vero and HeLa cells by the low pH-dependent LCMV (Armstrong strain) and influenza A/WSN/33 viruses, respectively

Formal name: 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Synonyms: 

Molecular weight: 346.2

CAS: 415687-81-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|Influenza

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