An inhibitor of the presynaptic choline transporter (Kis = 92 and 166 nM for HEK293 cells expressing with human CHT and mouse forebrain synaptosomes

ML-352 – 5 mg

Brand:
Cayman
CAS:
1649450-12-3
Storage:
-20
UN-No:
Non-Hazardous - /

ML-352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively.{42276} It is selective for CHT over dopamine, norepinephrine, and serotonin transporters in HEK293 cells expressing human transporters when used at a concentration of 5 μM as well as a panel of 68 G protein-coupled receptors, ion channels, and transporters when used at a concentration of 10 μM. ML-352 (5 μM) increases cell surface expression of CHT without affecting total protein levels.  

 

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Description

An inhibitor of the presynaptic choline transporter (Kis = 92 and 166 nM for HEK293 cells expressing with human CHT and mouse forebrain synaptosomes, respectively); selective for CHT over dopamine, norepinephrine, and serotonin transporters in HEK293 cells expressing human transporters at 5 μM and a panel of 68 G protein-coupled receptors, ion channels, and transporters at 10 μM; increases cell surface expression of CHT ,

Formal name: 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-benzamide

Synonyms: 

Molecular weight: 387.5

CAS: 1649450-12-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience

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