An inhibitor of Wnt signaling; inhibits Wnt signaling and colony formation in COLO-320DM and SW403

G244-LM – 5 mg

Brand:
Cayman
CAS:
1563007-08-8
Storage:
-20
UN-No:
Non-Hazardous - /

G244-LM is an inhibitor of Wnt signaling.{40727} It inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay. It also inhibits Wnt signaling and colony formation in COLO-320DM and SW403, but not HCT-15 or DLD-1, colorectal cancer cells when used at a concentration of 0.2 µM for seven to 13 days. G244-LM inhibits growth of mouse intestinal organoids (IC50 = 0.11 µM) and organoid spheroids cultured from small intestine adenomas isolated from ApcMin mice, which exhibit constitutively activated Wnt/β-catenin signaling.  

 

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Description

An inhibitor of Wnt signaling; inhibits Wnt signaling and colony formation in COLO-320DM and SW403, but not HCT-15 or DLD-1, colorectal cancer cells at 0.2 µM for 7-13 days; inhibits growth of mouse intestinal organoids (IC50 = 0.11 µM) and organoid spheroids cultured from small intestine adenomas isolated from ApcMin mice

Formal name: 3,5,7,8-tetrahydro-2-[4-[2-(methylsulfonyl)phenyl]-1-piperazinyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

Synonyms: 

Molecular weight: 406.5

CAS: 1563007-08-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|Wnt Signaling

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