A nitrogen mustard alkylating agent and a derivative of cyclophosphamide with antiproliferative activities; increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow at 40

Trofosfamide – 5 mg

Brand:
Cayman
CAS:
22089-22-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Trofosfamide is a nitrogen mustard alkylating agent and a derivative of cyclophosphamide (Item No. 13849) that has antiproliferative activities.{52010,52011} It increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow, indicating cytogenetic activity, when administered at doses of 40, 80, and 160 mg/kg.{52009} Trofosfamide (100 mg/kg) inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction.{52010} It reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats when administered at a dose of 40 mg/kg.{52011}  

 

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Description

A nitrogen mustard alkylating agent and a derivative of cyclophosphamide with antiproliferative activities; increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow at 40, 80, and 160 mg/kg; inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction at 100 mg/kg; reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats at 40 mg/kg

Formal name: N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide

Synonyms:  NSC 109723

Molecular weight: 323.6

CAS: 22089-22-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|DNA Alkylating Agents||Research Area|Immunology & Inflammation|Adaptive Immunity

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