A sodium channel inhibitor; also inhibits K+

Propafenone (hydrochloride) – 1 g

Brand:
Cayman
CAS:
34183-22-7
Storage:
-20
UN-No:
Non-Hazardous - /

Propafenone is an inhibitor of voltage-dependent sodium channels and a Class I antiarrhythmic drug.{34129} It also inhibits K+, KATP, and Ca2+ channels in cardiac cells.{34128,34127,34126} In transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively.{34130} Formulations containing propafenone are used to treat cardiac arrhythmia.  

 

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Description

A sodium channel inhibitor; also inhibits K+, KATP, and Ca2+ channels; in transfected HEK293 cells, it inhibits hKCa2.3 and hKCa2.2 channels with IC50 values of 42 and 80 µM, respectively

Formal name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride

Synonyms: 

Molecular weight: 377.9

CAS: 34183-22-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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