A potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM); has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors

PQ-10 – 25 mg

Brand:
Cayman
CAS:
927691-21-2
Storage:
-20
UN-No:
Non-Hazardous - /

PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM).{40045} It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats.{40046} PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.{40047}  

 

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Description

A potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM); has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro; increases striatal cGMP and CREB phosphorylation in vivo; reduces scopolamine- and MK-801-induced memory deficits in rats; inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively

Formal name: 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline

Synonyms: 

Molecular weight: 403.4

CAS: 927691-21-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cancer|Cell Signaling|cAMP Signaling||Research Area|Cancer|Cell Signaling|cGMP Signaling||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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