A selective inhibitor of MMP-8 (IC50 = 4 nM); does not target other MMPs

MMP-8 Inhibitor I – 1 mg

Brand:
Cayman
CAS:
236403-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.{34599} This inhibitor does not target the activities of other MMPs in vitro.{34587,34589} MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization.{34585} Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.{34586,34590}  

 

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Description

A selective inhibitor of MMP-8 (IC50 = 4 nM); does not target other MMPs

Formal name: (3R)-1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-3-isoquinolinecarboxamide

Synonyms:  Matrix Metalloproteinase-8 Inhibitor I

Molecular weight: 362.4

CAS: 236403-25-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Stem Cell Research

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