A selective agonist of σ2 receptor (IC50 = 0.19 nM); anxiolytic in animal studies and induces the death of cancer cells in vitro by destabilizing lysosomes

Siramesine (fumarate) – 5 mg

Brand:
Cayman
CAS:
163630-79-3
Storage:
-20
UN-No:
Non-Hazardous - /

Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM).{34005} It is selective for σ2 over σ1 (IC50 = 17 nM) and related receptors and transporters.{34005} Siramesine is anxiolytic without inducing sedation or impairing motor coordination in animal studies.{34005} It is known to induce the death of cancer cells in vitro by destabilizing lysosomes, although it has also been shown to destabilize mitochondria and, with lapatinib (Item No. 11493), induce ferroptosis.{34002,34003,34004}  

 

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Description

A selective agonist of σ2 receptor (IC50 = 0.19 nM); anxiolytic in animal studies and induces the death of cancer cells in vitro by destabilizing lysosomes

Formal name: 1′-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-spiro[isobenzofuran-1(3H),4′-piperidine], 2E-2-butenedioate

Synonyms:  Lu 28-179

Molecular weight: 570.7

CAS: 163630-79-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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