An orally bioavailable

GNE-495 – 25 mg

Brand:
Cayman
CAS:
1449277-10-4
Storage:
-20
UN-No:
Non-Hazardous - /

GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM).{34157} In cell sprouting assays, it increases the number of protrusions.{34158} In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.  

 

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Description

An orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM); showed positive effects on pathological angiogenesis

Formal name: 8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide

Synonyms: 

Molecular weight: 405.4

CAS: 1449277-10-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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