A fungal metabolite produced by A. terreus and Penicillium; inhibits eosinophil degranulation

Sulochrin – 1 mg

Brand:
Cayman
CAS:
519-57-3
Storage:
-20
UN-No:
Non-Hazardous - /

Sulochrin is a fungal metabolite produced by A. terreus and Penicillium that exhibits antiallergenic, anti-angiogenic, and antiviral activities. Sulochrin inhibits eosinophil degranulation.{39038} It prevents leukotriene C4 (LTC4) release, O2- production, and IL-8 production (IC50s = 0.03, 8.2, 9.6, and 8.7 μM, respectively) and inhibits migration of human and guinea pig eosinophils (IC50 = 0.2-0.4 μM). Sulochrin inhibits VEGF-induced capillary tube formation of human umbilical vein endothelial cells (HUVEC) in vitro (70% inhibition at 10 mg/ml).{25064} It also inhibits hepatitis C viral infection (IC50 = 24.4 μM) in vitro.{39039}  

 

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Description

A fungal metabolite produced by A. terreus and Penicillium; inhibits eosinophil degranulation, prevents LTC4 release, O2- production, and IL-8 production (IC50s = 0.03, 8.2, 9.6, and 8.7 μM, respectively); inhibits migration of human and guinea pig eosinophils (IC50 = 0.2-0.4 μM); inhibits VEGF-induced capillary tube formation of HUVECs in vitro (70% inhibition at 10 mg/ml); inhibits hepatitis C viral infection (IC50 = 24.4 μM) in vitro,

Formal name: 2-(2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxy-benzoic acid, methyl ester

Synonyms: 

Molecular weight: 332.3

CAS: 519-57-3

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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