A selective β2-AR agonist (EC50s = 97.7 and 2

Olodaterol – 1 mg

Brand:
Cayman
CAS:
868049-49-4
Storage:
-20
UN-No:
Non-Hazardous - /

Olodaterol is a selective agonist of β2-adrenergic receptors (β2-ARs; EC50s = 97.7 and 2,725 nM for human β2- and β1-ARs, respectively).{40022} In vivo, olodaterol completely reverses acetylcholine-induced bronchoconstriction without cardiovascular side effects in guinea pigs. It also exhibits dose-dependent bronchoprotection in a beagle model of acetylcholine-induced bronchoconstriction for a period of 24 hours, indicating potential for once-daily dosing.{40023} Formulations containing olodaterol have been used to treat bronchoconstriction associated with chronic obstructive pulmonary disease.{40024}  

 

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Description

A selective β2-AR agonist (EC50s = 97.7 and 2,725 nM for human β2- and β1-ARs, respectively); completely reverses acetylcholine-induced bronchoconstriction without cardiovascular side effects in guinea pigs; exhibits dose-dependent bronchoprotection in a beagle model of acetylcholine-induced bronchoconstriction,

Formal name: 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one

Synonyms:  BI-1744

Molecular weight: 386.4

CAS: 868049-49-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area

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