An α1-adrenergic receptor agonist (Kis = 120

Cirazoline (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
40600-13-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes).{41231} It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum.{41105} Cirazoline (0.01-1 µg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats.{36359} It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months.{35157} It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 µg/kg but impairs performance at lower doses of 0.01-1 µg/kg.{35155}  

 

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Description

An α1-adrenergic receptor agonist (Kis = 120, 960, and 660 nM at α1A-, α1B-, and α1D-ARs, respectively); a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs (EC50s = 70.7, 79.4, and 239.8 nM, respectively); decreases blood pressure when microinjected into the NRL of the brainstem of anesthetized cats at doses ranging from 0.01-1 µg/kg; enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water; enhances memory in aged rhesus monkeys at high doses of 1-10 µg/kg but impairs performance at lower doses of 0.01-1 µg/kg

Formal name: 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole, monohydrochloride

Synonyms: 

Molecular weight: 252.7

CAS: 40600-13-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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