A major phase 2 metabolite of pitavastatin; formed when pitavastatin undergoes glucuronidation by UGT1A1

Pitavastatin lactone – 1 mg

Brand:
Cayman
CAS:
141750-63-2
Storage:
4
UN-No:
Non-Hazardous - /

Pitavastatin lactone is a major phase 2 metabolite of pitavastatin (Item No. 15414), an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration.{37247},{25250} Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyl transferases UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be converted back to pitavastatin via hydrolysis.  

 

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Description

A major phase 2 metabolite of pitavastatin; formed when pitavastatin undergoes glucuronidation by UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide which then undergoes non-enzymatic conversion to the lactone form, can be converted back to pitavastatin via hydrolysis

Formal name: 6S-[(1E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4R-hydroxy-2H-pyran-2-one

Synonyms: 

Molecular weight: 403.5

CAS: 141750-63-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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