A Hec1/Nek2 inhibitor; inhibits proliferation in human breast

INH6 – 1 mg

Brand:
Cayman
CAS:
1001753-24-7
Storage:
-20
UN-No:
Non-Hazardous - /

INH6 is an inhibitor of the oncogene high expression in cancer 1 (Hec1) and its regulator, the serine-threonine kinase Nek2, which together regulate mitotic spindle formation.{38094,38095} It inhibits proliferation in human breast, cervical, and leukemia cell lines with IC50 values of 1.7 and 2.1, 2.4, and 2.5 µM, respectively, for MDA-MB-231 and MDA-MB-468, HeLa, and K562 cells.{38094} INH6 co-precipitates with cellular Hec1, reduces Nek2 protein levels when administered to HeLa cells at 6.25 µM, disrupts spindle formation, and induces apoptosis.  

 

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Description

A Hec1/Nek2 inhibitor; inhibits proliferation in human breast, cervical, and leukemia cell lines with IC50 values of 1.7 and 2.1, 2.4, and 2.5 µM, respectively, for MDA-MB-231 and MDA-MB-468, HeLa, and K562 cells; co-precipitates with cellular Hec1; reduces Nek2 protein levels (at 6.25 µM); disrupts spindle formation; induces apoptosis,

Formal name: N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide

Synonyms: 

Molecular weight: 322.4

CAS: 1001753-24-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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