An inhibitor of the USP1/UAF complex; inhibits USP1/UAF deubiquitinase activity (IC50 = 0.88 µM); inhibits USP5

C527 – 5 mg

Brand:
Cayman
CAS:
192718-06-2
Storage:
-20
UN-No:
Non-Hazardous - /

C527 is an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 0.88 µM).{36957} It also inhibits USP5, UCL-H3, and USP12/46 but not UCL-H1 activity (IC50s = 1.65, 2.18, 5.97, and >10 µM, respectively). C527 increases ubiquinated Fanconi anemia complementation group D2 (FANCD2-Ub) and FANCI-Ub levels in a concentration-dependent manner. It inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C (Item No. 11435). C527 also inhibits proliferation of PC3 and LNCap prostate cancer cells (IC50s = 0.24 and 0.03 µM, respectively, after 72 hours).{36958}  

 

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Description

An inhibitor of the USP1/UAF complex; inhibits USP1/UAF deubiquitinase activity (IC50 = 0.88 µM); inhibits USP5, UCL-H3, and USP12/46 but not UCL-H1 activity (IC50s = 1.65, 2.18, 5.97, and >10 µM, respectively); inhibits homologous recombination repair, cell proliferation, and sensitizes HeLa cells to the DNA crosslinker mitomycin C; inhibits proliferation of PC3 and LNCap prostate cancer cells (IC50s = 0.24 and 0.03 µM, respectively, after 72 hours)

Formal name: 2-(4-fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione

Synonyms: 

Molecular weight: 293.3

CAS: 192718-06-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|DNA Damage and Repair

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