An Hsp90 inhibitor; disrupts Hsp90 and Cdc37 binding; inhibits cell proliferation in HER2+ breast cancer cells (IC50 = 12.9-61.5 µM

Conglobatin – 2.5 mg

Brand:
Cayman
CAS:
72263-05-9
Storage:
-20
UN-No:
Non-Hazardous - /

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus.{39047} It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells.{39043} It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 µM, respectively) and decreases the number of invasive cells in vitro.{39043,39046} When combined with lapatinib (Item No. 11493), tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone.{39044} Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 µM).{39045} It also inhibits β1 integrin activation leading to a loss of cellular adhesion.  

 

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Description

An Hsp90 inhibitor; disrupts Hsp90 and Cdc37 binding; inhibits cell proliferation in HER2+ breast cancer cells (IC50 = 12.9-61.5 µM, respectively); decreases the number of invasive cells in vitro; inhibits cell proliferation in KYSE510 cells with an IC50 value of 9.31 µM; inhibits β integrin ,

Formal name: (3E,5R,11E)-3,5,7S,11,13R,15S-hexamethyl-8S,16S-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

Synonyms: 

Molecular weight: 498.6

CAS: 72263-05-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|ECM & Adhesion Molecules

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