A fungal macrolactone that has cytotoxic activity against select cancer cell lines; inhibits cytokine-induced iNOS expression (IC50 = 9.5 µM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis

Curvularin – 1 mg

Brand:
Cayman
CAS:
10140-70-2
Storage:
-20
UN-No:
Non-Hazardous - /

Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines.{34313,34316} It inhibits cytokine-induced expression of induced nitric oxide synthase (iNOS; IC50 = 9.5 µM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis.{32339,34321} Curvularin also blocks TGF-β signaling in HepG2 and MDA-MB-231 cells.{34314}  

 

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Description

A fungal macrolactone that has cytotoxic activity against select cancer cell lines; inhibits cytokine-induced iNOS expression (IC50 = 9.5 µM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis

Formal name: (4S)-4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione

Synonyms:  (-)-Curvularin|(S)-Curvularin|NSC 166071

Molecular weight: 292.3

CAS: 10140-70-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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