An antiparasitic and antimicrobial 5-nitroimidazole derivative; metabolized to cytotoxic intermediates that induce irreversible DNA damage; efficacious against clinically significant bacteria and protozoa

Tinidazole – 10 g

Brand:
Cayman
CAS:
19387-91-8
Storage:
-20
UN-No:
Non-Hazardous - /

Tinidazole is a 5-nitroimidazole derivative with antiparasitic and antibiotic activity that exhibits a mean minimum inhibitory concentration of 0.31, 2.33, and 0.5 μg/mL against C. difficile, P. bivia, and B. fragilis, respectively.{34365,34366} It is orally bioavailable and is rapidly metabolized to cytotoxic intermediates that covalently bind DNA, causing irreversible damage to susceptible cells.{34365,34366} It shows efficacy against pathogenic protozoa (T. vaginalis, E. bistolytica, and G. duodenalis), clinically significant anaerobic bacteria (B. fragilis, C. difficile), and microaerophilic bacterium (H. pylori).{34366}  

 

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Description

An antiparasitic and antimicrobial 5-nitroimidazole derivative; metabolized to cytotoxic intermediates that induce irreversible DNA damage; efficacious against clinically significant bacteria and protozoa

Formal name: 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole

Synonyms:  CP 12,574

Molecular weight: 247.3

CAS: 19387-91-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Giardiasis||Research Area|Infectious Disease|Parasitic Diseases|Trichomoniasis

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