A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM

MK-886 – 10 mg

Brand:
Cayman
CAS:
118414-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

MK-886 is a potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.{2078} In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.  

 

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Description

A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM

Formal name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid

Synonyms:  L-663,536

Molecular weight: 472.1

CAS: 118414-82-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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