A synthetic progestogen; binds to progesterone

Megestryl Acetate – 5 g

Brand:
Cayman
CAS:
595-33-5
Storage:
-20
UN-No:
Non-Hazardous - /

Megestryl acetate is a synthetic progestogen and derivative of progesterone originally developed as a contraceptive.{38302} It binds with high relative affinity to the progesterone (Item No. 15876), androgen, and glucocorticoid receptors in mammary cancer cells.{38303} It increases neuropeptide Y (Item No. 15071) by 90-140% and inhibits calcium channel currents in the rat hypothalamus.{38301,38299} Megestryl acetate decreases cytokine and serotonin production in patient-derived peripheral blood mononuclear cells (PBMCs).{38300} In rats, it increases food and water intake when administered at a dose of 50 mg/kg per day.{38301} Formulations containing megestryl acetate have been used in the treatment of endometriosis, hormone-related cancers, and as an appetite stimulant for cancer patients with anorexia and cachexia.{38304}  

 

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Description

A synthetic progestogen; binds to progesterone, androgen, and glucocorticoid receptors; increases neuropeptide Y by 90-140% in the hypothalamus; inhibits calcium channel currents in the rat hypothalamus; decreases cytokine and serotonin production in patient-derived PBMCs; increases food and water intake when administered at a dose of 50 mg/kg per day in rats,

Formal name: 17-(acetyloxy)-6-methyl-pregna-4,6-diene-3,20-dione

Synonyms:  Megestrol Acetate|NSC 71423|SC-10363

Molecular weight: 384.5

CAS: 595-33-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Reproductive Biology

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