An immunosuppressive compound that inhibits IMP dehydrogenase (Ki = 30-45 nM); blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes

Mycophenolic Acid – 100 mg

Brand:
Cayman
CAS:
24280-93-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Mycophenolic Acid is an immunosuppressive natural product that inhibits inosine monophosphate dehydrogenase (IC50 = 11 nM; Ki = 30-45 nM).{33309,33310,21841} Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation.{21841} It has antifungal, antibacterial, antitumor, and antiviral properties.{33313,33312,33311} Mycophenolic acid, typically used in clinical settings as a chemotherapeutic or immunosuppressant agent, is rapidly conjugated on absorption and circulates mostly in the form of its glucuronide conjugate.{21841,21839,21840}  

 

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Description

An immunosuppressive compound that inhibits IMP dehydrogenase (Ki = 30-45 nM); blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation; has antifungal, antibacterial, anti-tumor and anti-viral properties

Formal name: (4E)-6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Synonyms:  MPA|NSC 129185

Molecular weight: 320.3

CAS: 24280-93-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Viral Diseases

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