A monoterpene; found in the essential oils of various plants

Terpinolene – 500 mg

Brand:
Cayman
CAS:
586-62-9
Storage:
-20
UN-No:
- 2541 / 3

Terpinolene is a monoterpene found in the essential oils of various plants, including C. sativa, and has diverse biological activities including antiproliferative and antioxidant properties.{42314,42303,39962,39963,39964} It inhibits expression of AKT1 in Jurkat and K562 cells by 95% when used at a concentration of 0.05% and inhibits the growth of K562 cells when used at a concentration of 0.01%.{39962} Terpinolene also inhibits the growth of HT-29, Hep-2, NCI-292, and HL-60 cells (IC50s = 16.7, 13.7, 17.4, and 28.8 μg/ml, respectively).{39963} In cultured human blood cells, terpinolene (10-75 mg/L) increases total antioxidant capacity (TAC), but decreases cell viability when used at a concentration of ≥150 mg/L.{39964}  

 

Out of stock

Add to quotes
SKU: 21712 - Category:

Description

A monoterpene; found in the essential oils of various plants, including C. sativa; has diverse biological activities; inhibits expression of AKT1 in Jurkat and K562 cells by 95% at 0.05%; inhibits the growth of K562 cells at 0.01%; inhibits the growth of HT-29, Hep-2, NCI-292, and HL-60 cells (IC50s = 16.7, 13.7, 17.4, and 28.8 μg/ml, respectively); increases TAC in cultured human blood cells at 10-75 mg/L, but decreases cell viability at ≥150 mg/L

Formal name: 1-methyl-4-(1-methylethylidene)-cyclohexene

Synonyms:  4-Isopropylidene-1-Methylcyclohexene|p-Meth-1-en-8-yl-formate|α-Terpinolene|δ-Terpinene

Molecular weight: 136.2

CAS: 586-62-9

Purity: ≥85%

Formulation: An oil

Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 500 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 500 mg

    Available on backorder

    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 5 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 5 mg

    Available on backorder

    Add to quotes
    View product page