An isomer of guanine; found naturally but also formed through oxidative damage to DNA; mutagenic in mammalian and bacterial cells in vitro

Isoguanine – 50 mg

Brand:
Cayman
CAS:
3373-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

Isoguanine is a natural isomer of guanine originally isolated from Croton seed but is also a product of oxidative damage to the adenine base in DNA.{38758,38759} It can be formed through oxidative damage to deoxyadenosine and deoxyadenosine-ATP (d-ATP) as well as single- and double-stranded DNA and induces a parallel-stranded DNA structure when incorporated into DNA.{38759,38760} It is mutagenic to S. tymphimurium in the Ames test and induces sister chromatid exchange, a measure of mutagenicity, in isolated human peripheral blood lymphocytes.{38761}  

 

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Description

An isomer of guanine; found naturally but also formed through oxidative damage to DNA; mutagenic in mammalian and bacterial cells in vitro

Formal name: 6-amino-3,7-dihydro-2H-purin-2-one

Synonyms:  2-hydroxy-6-Aminopurine|2-Hydroxyadenine|2-Oxoadenine|Crotonoside|NSC 241501

Molecular weight: 151.1

CAS: 3373-53-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Oxidative Stress & Reactive Species|DNA/RNA Oxidative Damage||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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