A Na+/K+-ATPase inhibitor; cardiac glycoside metabolite of digoxin; has a binding affinity of 0.829 relative to [3H]ouabain; has an inhibitory potency of 1.07 relative to [3H]ouabain for its ATPase activity; selective for the α3β1 isoform over α1β1 and α2β1 (Kds = 31.8

Digoxigenin Monodigitoxoside – 1 mg

Brand:
Cayman
CAS:
5352-63-6
Storage:
-20
UN-No:
- 2811 / 6.1

Digoxigenin monodigitoxoside is a Na+/K+-ATPase inhibitor and cardiac glycoside metabolite of digoxin (Item No. 22266).{35125} It has a binding affinity of 0.829 and an inhibitory potency of 1.07 relative to [3H]ouabain in a competitive binding assay using purified lamb Na+/K+-ATPase and for its ATPase activity, respectively.{35127} Digoxigenin monodigitoxoside is selective for the α3β1 isoform over α1β1 and α2β1 (Kds = 31.8, 65, and 35 nM, respectively).{29469} Digoxigenin monodigitoxoside produces a more potent inotropic response in perfused guinea pig hearts than digoxin with 60 and 46% increases in inotropy, respectively.{35125}  

 

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Description

A Na+/K+-ATPase inhibitor; cardiac glycoside metabolite of digoxin; has a binding affinity of 0.829 relative to [3H]ouabain; has an inhibitory potency of 1.07 relative to [3H]ouabain for its ATPase activity; selective for the α3β1 isoform over α1β1 and α2β1 (Kds = 31.8, 65, and 35 nM, respectively); produces a more potent inotropic response in perfused guinea pig hearts than digoxin (60 and 46% increases in inotropy, respectively)

Formal name: (3β,5β,12β)-3-[(2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide

Synonyms: 

Molecular weight: 520.7

CAS: 5352-63-6

Purity: ≥97%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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