A natural retinoid that is produced by oxidation of 9-cis retinol by cRDH; binds to CRBP-I

9-cis Retinal – 10 mg

Brand:
Cayman
CAS:
514-85-2
Storage:
-20
UN-No:
Non-Hazardous - /

9-cis Retinal is a natural retinoid that is produced by oxidation of 9-cis retinol by cis-retinol dehydrogenase (cRDH).{37448} It binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II (Kds = 8 and 5 nM, respectively) and to cellular retinaldehyde-binding protein (CRALBP; Kd = 53.3 nM).{37449,37550} In vitro, 9-cis retinal inhibits differentiation of RCJ C5.18 chondrogenic cells into cartilage (IC50 = 8 nM).{37551} In vivo, it rescues cone electroretinogram (ERG) responses in Irbp-/- mice, which lack interphotoreceptor retinoid-binding protein and have diminished cone responses, when administered at a dose of 0.375 mg.{37552}  

 

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Description

A natural retinoid that is produced by oxidation of 9-cis retinol by cRDH; binds to CRBP-I, CRBP-II, and CRALBP (Kds = 8, 5, and 53.3 nM, respectively); inhibits differentiation of RCJ C5.18 chondrogenic cells into cartilage in vitro (IC50 = 8 nM); it rescues cone ERG responses in Irbp-/- mice (0.375 mg)

Formal name: 9-cis-retinal

Synonyms:  9-cis Retinaldehyde|9-cis Vitamin A aldehyde

Molecular weight: 284.4

CAS: 514-85-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Research Area|Neuroscience|Ophthalmology

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