A major active metabolite of flurbiprofen

4′-hydroxy Flurbiprofen – 1 mg

Brand:
Cayman
CAS:
52807-12-2
Storage:
-20
UN-No:
- 2811 / 6.1

4′-hydroxy Flurbiprofen is a major active metabolite of the COX inhibitor flurbiprofen (Item No. 70250) and its enantiomers (R)-flurbiprofen (Item No. 70255) and (S)-flurbiprofen (Item No. 10004207).{48402} It is formed from flurbiprofen by the cytochrome P450 (CYP) isoform CYP2C9, including CYP2C9 containing an R144C substitution mutation. 4’-hydroxy Flurbiprofen inhibits COX-1 by 94% at a concentration of 1,000 µM but does not inhibit cyclooxygenation of arachidonic acid.{48403} It completely inhibits cyclooxygenation of 2-arachidonoyl glycerol (2-AG; Item No. 62160) when used at a concentration of 300 µM. 4′-hydroxy Flurbiprofen inhibits fatty acid amide hydrolase (FAAH) hydrolysis of anandamide in rat brain homogenates with an IC50 value of 84 µM at a pH of 6.  

 

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Description

A major active metabolite of flurbiprofen, (R)-flurbiprofen, and (S)-flurbiprofen; inhibits COX-1 by 94% at 1,000 µM but does not inhibit oxygenation of arachidonic acid; completely inhibits cyclooxygenation of 2-AG at 300 µM; inhibits FAAH hydrolysis of anandamide in rat brain homogenates (IC50 = 84 µM at a pH of 6)

Formal name: 2-fluoro-4′-hydroxy-α-methyl-[1,1′-biphenyl]-4-acetic acid

Synonyms: 

Molecular weight: 260.3

CAS: 52807-12-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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