A non-competitive inhibitor of guanylyl and adenylyl cyclases; suppresses STa-

BPIPP – 1 mg

Brand:
Cayman
CAS:
325746-94-9
Storage:
-20
UN-No:
Non-Hazardous - /

BPIPP is a non-competitive inhibitor of guanylyl and adenylyl cyclases that suppresses cGMP accumulation induced by stable toxin (STa), guanylin, atrial natriuretic peptide (Item Nos. 24539 | 24276), and C-type natriuretic peptide (Item No. 24401) in vitro (IC50s = 3.4-11.2 μM).{39640} It inhibits chloride efflux induced by STa, forskolin (Item No. 11018), cholera toxin (Item No. 19654), and isoproterenol (Item No. 15592) in T84 cells but has no effect on basal chloride efflux. BPIPP (10 or 50 μM) suppresses STa-induced liquid secretion in a rabbit intestinal loop model of toxin-induced secretory diarrhea.  

 

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Description

A non-competitive inhibitor of guanylyl and adenylyl cyclases; suppresses STa-, guanylin-, atrial natriuretic peptide-, and C-type natriuretic peptide-induced cGMP accumulation in cells (IC50s = 3.4-11.2 μM); inhibits STa-, forskolin-, cholera toxin-, and isoproterenol-induced chloride efflux in T84 cells; suppresses STa-induced liquid secretion in a rabbit intestinal loop model of toxin-induced secretory diarrhea (10 or 50 μM) ,

Formal name: 5-(3-bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione

Synonyms: 

Molecular weight: 450.3

CAS: 325746-94-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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