A retinoid; increases the doubling time and transcription of RARβ mRNA in various human oral squamous cell carcinoma cells at 1 μM; inhibits proliferation of primary human sebocytes (IC50 = 10 μM); decreases triglyceride

Isotretinoin – 1 g

Brand:
Cayman
CAS:
4759-48-2
Storage:
-20
UN-No:
Non-Hazardous - /

Isotretinoin is a retinoid that is converted in vivo into all-trans retinoic acid (Item No. 11017) and has diverse biological activities.{40199,39853,39854,39855} It increases the doubling time and transcription of retinoic acid receptor β (RARβ) mRNA in Hep2, FaDu, CCL-17, SCC-9, SCC-15, and SCC-25 human oral squamous cell carcinoma cells when used at a concentration of 1 μM.{39853} Isotretinoin inhibits proliferation of primary human sebocytes (IC50 = 10 μM).{39854} It also decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at a concentration of 0.1 μM. Isotretinoin (2 mg/kg per day) reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice, an allograft nephropathy model.{39855} It also slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration when administered at a dose of 40 mg/kg.{39856} Formulations containing isotretinoin have been used in the treatment of severe recalcitrant nodular acne.  

 

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Description

A retinoid; increases the doubling time and transcription of RARβ mRNA in various human oral squamous cell carcinoma cells at 1 μM; inhibits proliferation of primary human sebocytes (IC50 = 10 μM); decreases triglyceride, stearyl ester, and free fatty acid synthesis and modulates keratin expression in primary human sebocytes at 0.1 μM; reduces chronic rejection damage and decreases mRNA expression of IFN-γ and IL-10 in allografts in chronic Fisher344➛Lewis transplant mice at 2 mg/kg per day; slows rod and cone recovery and prevents light-induced photoreceptor damage in an albino rat model of photoreceptor degeneration at 40 mg/kg

Formal name: 13-cis-retinoic acid

Synonyms:  13(Z)-Retinoic Acid|13-cis-Vitamin A Acid|AGN 190013

Molecular weight: 300.4

CAS: 4759-48-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience|Ophthalmology

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