A selective antagonist of TRPM8 that blocks activation by cold

M8-B (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
883976-12-3
Storage:
-20
UN-No:
Non-Hazardous - /

M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Item No. 10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively).{34008} It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.{34008}  

 

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Description

A selective antagonist of TRPM8 that blocks activation by cold, icilin, or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively); decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 knockout mice

Formal name: N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride

Synonyms: 

Molecular weight: 433

CAS: 883976-12-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience

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