An allosteric activator of AMPK heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1

ZLN024 – 50 mg

Brand:
Cayman
CAS:
723249-01-2
Storage:
-20
UN-No:
Non-Hazardous - /

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively).{33850} Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein phosphatase 2Cα.{33850} ZLN024 stimulates glucose uptake and fatty acid oxidation in L6 myotubes. In primary hepatocytes, ZLN024 decreases fatty acid synthesis and glucose output.{33850} ZLN024 reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice.{33850}  

 

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Description

An allosteric activator of AMPK heterotrimers (EC50s = 0.42 and 0.95 µM for α1β1γ1 and α2β1γ1, respectively); reduces liver triacylglycerol and total cholesterol content and improves glucose tolerance in db/db mice

Formal name: 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine

Synonyms: 

Molecular weight: 325.2

CAS: 723249-01-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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