UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) (Item No. 15602). The activities of the UDP-β-D-glucose isomer are not known.
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A stereoisomer of UDP-α-D-glucose
Formal name: uridine 5′-(trihydrogen pyrophosphate), mono-β-D-glucopyranosyl ester, disodium salt
Synonyms: NSC 20269|UDPG|UDP-Glucose|Uridine-5′-diphosphoglucose
Molecular weight: 610.3
CAS: 7333-33-7
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism
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The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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