A prodrug of the HIV-1 protease inhibitor amprenavir; improved solubility and pharmacokinetics compared with amprenavir and other HIV treatments

Fosamprenavir (calcium salt) – 1 mg

Brand:
Cayman
CAS:
226700-81-8
Storage:
-20
UN-No:
Non-Hazardous - /

Fosamprenavir (calcium salt) is an orally bioavailable prodrug of the HIV-1 protease inhibitor amprenavir (Item No. 15369).{34191} Fosamprenavir has improved solubility compared with amprenavir, and its pharmacokinetics, either during fasting or with a low- or high-fat meal, suggest that it could be effective using fewer tablets and a less complex dosing schedule than other HIV treatments.{34192} Formulations containing fosamprenavir are used for adult and pediatric patients with HIV infection, especially as an initial antiretroviral therapy.{34193}  

 

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Description

A prodrug of the HIV-1 protease inhibitor amprenavir; improved solubility and pharmacokinetics compared with amprenavir and other HIV treatments

Formal name: N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-carbamic acid, (3S)-tetrahydro-3-furanyl ester, monocalcium salt

Synonyms:  GW 433908G

Molecular weight: 623.7

CAS: 226700-81-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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