A PPARα agonist; induces CYP4A6 expression via PPARα activation in RK13 rabbit kidney cells (EC50 = 80 µM); decreases OVCAR-3 xenograft tumor growth and vascularity in a mouse OVCAR-3 xenograft model when used as a dietary supplement; exposure to 20 mg/L in water increases the expression of several known PPARα target genes and enhances acyl-CoA oxidase activity in carp

Clofibric Acid – 25 g

Brand:
Cayman
CAS:
882-09-7
Storage:
-20
UN-No:
Non-Hazardous - /

Clofibric acid is an agonist of peroxisome proliferator-activated receptor α (PPARα). It induces CYP4A6 expression via PPARα activation in RK13 rabbit kidney cells, with an EC50 value of 80 µM.{37343} Clofibric acid also induces carbonyl reductase and bifunctional enzyme expression in the OVCAR-3 human ovarian cell line at a concentration of 500 µM, and decreases OVCAR-3 xenograft tumor growth and vascularity in a mouse OVCAR-3 xenograft model when used as a dietary supplement.{37344} Subcutaneous injection of clofibric acid (200 mg/kg) induces the Δ6 desaturation of linoleic acid to 6,9,12-octadecatrienoic acid, and dietary supplementation with 0.5% (w/w) significantly enhances microsomal steroyl-CoA desaturase activity in rat liver.{37342},{37341} In carp, exposure to 20 mg/L clofibric acid in water increases the expression of several known PPARα target genes and enhances acyl-CoA oxidase activity.{37340}  

 

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Description

A PPARα agonist; induces CYP4A6 expression via PPARα activation in RK13 rabbit kidney cells (EC50 = 80 µM); decreases OVCAR-3 xenograft tumor growth and vascularity in a mouse OVCAR-3 xenograft model when used as a dietary supplement; exposure to 20 mg/L in water increases the expression of several known PPARα target genes and enhances acyl-CoA oxidase activity in carp

Formal name: 2-(4-chlorophenoxy)-2-methyl-propanoic acid

Synonyms:  NSC 1149

Molecular weight: 214.6

CAS: 882-09-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Metabolism

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