An orally bioavailable inhibitor of L-

Benidipine (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
91599-74-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels.{34214} In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology.{34216} It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury.{34213,34215,34211} Benidipine is also a competitive antagonist at mineralocorticoid receptors.{34214}  

 

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Description

An orally bioavailable inhibitor of L-, T-, and N-type calcium channels; IC50 = 2.7 nM in guinea pig ventricular cells; prevents oxidative stress in vitro and in neural stem cells; has antihypertensive effects; competitive antagonist at mineralocorticoid receptors

Formal name: (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, monohydrochloride

Synonyms:  (±)-Benidipine|KW-3049

Molecular weight: 542

CAS: 91599-74-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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