Description
A PRMT5 inhibitor (IC50 = 22 nM); selective for PRMT5 over a panel of 32 methyltransferases at 1 μM; reduces symmetric demethylation of SmBB’ in MCF-7 cells (IC50 = 25 nM); reduces proliferation of various cancer cell lines (IC50s = 3-30 nM); inhibits tumor growth in an A375 mouse xenograft model at 20 mg/kg
Formal name: 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Synonyms:
Molecular weight: 342.4
CAS: 2040291-27-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation
