A PRMT5 inhibitor (IC50 = 22 nM); selective for PRMT5 over a panel of 32 methyltransferases at 1 μM; reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM); reduces proliferation of various cancer cell lines (IC50s = 3-30 nM); inhibits tumor growth in an A375 mouse xenograft model at 20 mg/kg

LLY-283 – 1 mg

Brand:
Cayman
CAS:
2040291-27-6
Storage:
-20
UN-No:
- /

LLY-283 is an inhibitor of protein arginine methyltransferase 5 (PRMT5; IC50 = 22 nM).{43789} It is selective for PRMT5 over a panel of 32 methyltransferases, including PRMT4, -6, and -7 at 1 μM. LLY-283 reduces symmetric demethylation of SmBB’ in MCF-7 cells (IC50 = 25 nM). It reduces proliferation of various breast, gastric, hematological, lung, skin, and ovarian cancer cell lines (IC50s = 3-30 nM). LLY-283 (20 mg/kg) inhibits tumor growth in an A375 mouse xenograft model. See the Structural Genomics Consortium (SGC) website for more information.  

 

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Description

A PRMT5 inhibitor (IC50 = 22 nM); selective for PRMT5 over a panel of 32 methyltransferases at 1 μM; reduces symmetric demethylation of SmBB’ in MCF-7 cells (IC50 = 25 nM); reduces proliferation of various cancer cell lines (IC50s = 3-30 nM); inhibits tumor growth in an A375 mouse xenograft model at 20 mg/kg

Formal name: 7-[(5R)-5-C-phenyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms: 

Molecular weight: 342.4

CAS: 2040291-27-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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