A potent inhibitor of SRPK1 (IC50 = 5.9 nM); inhibits phosphorylation of SRSF1

SPHINX31 – 25 mg

Brand:
Cayman
CAS:
1818389-84-2
Storage:
-20
UN-No:
Non-Hazardous - /

SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).{33350} It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization.  

 

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Description

A potent inhibitor of SRPK1 (IC50 = 5.9 nM); inhibits phosphorylation of SRSF1, an SRPK1 substrate, in PC3 cells (EC50 = 360 nM); increases expression of the anti-angiogenic VEGF-A165b splice variant in RPE cells; inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization (2 μg per eye)

Formal name: 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide

Synonyms: 

Molecular weight: 507.5

CAS: 1818389-84-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling||Research Area|Neuroscience|Ophthalmology

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