A selective inhibitor of STAT3 that induces apoptosis in BRCA-mutated ovarian cancer cells with minimal toxicity to normal cells

HO-3867 – 5 mg

Brand:
Cayman
CAS:
1172133-28-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

HO-3867 is an analog of curcumin (Item No. 81025) that selectively suppresses STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.{33423,33421} It has been shown to induce apoptosis in BRCA-mutated ovarian cancer cells with minimal toxicity to normal cells.{33421,33422} HO-3867 is reported to demonstrate synergistic inhibition of chemotherapy-resistant ovarian xenograft tumors when combined with cisplatin (Item No. 13119).{33423,33421}  

 

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Description

A selective inhibitor of STAT3 that induces apoptosis in BRCA-mutated ovarian cancer cells with minimal toxicity to normal cells

Formal name: (3E,5E)-1-[(2,5-dihydro-1-hydroxy-2,2,5,5-tetramethyl-1H-pyrrol-3-yl)methyl]-3,5-bis[(4-fluorophenyl)methylene]-4-piperidinone

Synonyms: 

Molecular weight: 464.6

CAS: 1172133-28-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs

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