A mycotoxin with broad spectrum antibiotic activity against Gram positive and Gram negative bacteria; acted synergistically at 4-16 mg/L in vitro with erythromycin (500-2

Helvolic Acid – 1 mg

Brand:
Cayman
CAS:
29400-42-8
Storage:
-20
UN-No:
Non-Hazardous - /

Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria.{33797,33799} At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus.{33798} At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.{33800}  

 

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Description

A mycotoxin with broad spectrum antibiotic activity against Gram positive and Gram negative bacteria; acted synergistically at 4-16 mg/L in vitro with erythromycin (500-2,000 mg/L) against multi-drug resistant strains of S. aureus; reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma

Formal name: (4α,6β,8α,9β,13α,14β,16β,17Z)-6,16-bis(acetyloxy)-3,7-dioxo-29-nordammara-1,17(20),24-trien-21-oic acid

Synonyms:  BRN 3230584|Fumigacin|NSC 319943

Molecular weight: 568.7

CAS: 29400-42-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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