A bicyclic monoterpene with diverse biological activities; reduces the growth of a panel of seven Gram-positive bacteria

α-Pinene – 50 mg

Brand:
Cayman
CAS:
80-56-8
Storage:
-20
UN-No:
- 2368 / 3

α-Pinene is a bicyclic monoterpene found in pine trees and other plants, including Cannabis with diverse biological activities.{21071} It reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains with MIC values of 0.75-1.29, 1.05-1.59, and 0.7-1.17%, respectively.{42316} It has insecticidal activity against C. molestus larvae with LC50 values ranging from 47 to 49 mg/L.{42317} α-Pinene (100 μg/ml) induces apoptosis, increases anion superoxide production and DNA fragmentation, and activates caspase-3 in B16/F10 melanoma cells.{42315} In a B16/F10 mouse xenograft model, α-pinene (100 ml of a 10 mg/ml solution) reduces the number of metastatic lung nodules by approximately 7-fold. α-Pinene (8.6 mg/L, aerosol) also increases the time spent in the open arms of the elevated plus maze by approximately 2-fold in mice, indicating anxiolytic-like activity.{42318}  

 

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Description

A bicyclic monoterpene with diverse biological activities; reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains (MICs = 0.75-1.29, 1.05-1.59, and 0.7-1.17% v/v, respectively); has insecticidal activity against C. molestus larvae (LC50s = 47-49 mg/L); induces apoptosis, increases anion superoxide production and DNA fragmentation, and activates caspase-3 in B16/F10 melanoma cells at 100 μg/ml; reduces the number of metastatic lung nodules in a B16/F10 mouse xenograft model at 100 ml of a 10 mg/ml solution; increases the time spent in the open arms of the elevated plus maze in mice at 8.6 mg/L, aerosol,

Formal name: 2,6,6-trimethyl-bicyclo[3.1.1]hept-2-ene

Synonyms:  NSC 7727

Molecular weight: 136.2

CAS: 80-56-8

Purity: ≥95%

Formulation: A neat oil

Application||Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|DNA Damage and Repair||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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