An α7-containing nAChR agonist; activates human α7-containing nAChRs to 60% of the levels generated by endogenous ligand acetylcholine; has no activity at α2-

GTS-21 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
156223-05-1
Storage:
-20
UN-No:
Non-Hazardous - /

GTS-21 is an agonist of α7-containing nicotinic acetylcholine receptors (nAChRs) that, at a concentration of 100 μM, activates human α7-containing nAChRs expressed in Xenopus oocytes to 60% of the levels generated by endogenous ligand acetylcholine.{36257} It is selective for α7-containing nAChRs, having no activity at α2-, α3-, and α4-containing nAChRs at a concentration of 100 μM. GTS-21 stimulates dopamine release from rat striatal slices (EC50 = 10 μM).{36258} In vivo, GTS-21 decreases delay in the delayed matching-to-sample task in monkeys. It also suppresses amnesia and neuronal cell death in a gerbil model of ischemia-reperfusion injury.{36259}  

 

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Description

An α7-containing nAChR agonist; activates human α7-containing nAChRs to 60% of the levels generated by endogenous ligand acetylcholine; has no activity at α2-, α3-, and α4-containing nAChRs at a concentration of 100 μM; stimulates dopamine release from rat striatal slices (EC50 = 10 μM); decreases delay in the delayed matching-to-sample task in monkeys; suppresses amnesia and neuronal cell death in a gerbil model of ischemia-reperfusion injury

Formal name: (3E)-3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3′-bipyridine, dihydrochloride

Synonyms:  DMXB-A

Molecular weight: 381.3

CAS: 156223-05-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neuroprotection|Ischemia

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