An NMDA receptor antagonist (Ki = 0.14 µM); binds to NMDA receptors containing GluN2A

(R)-CPP – 1 mg

Brand:
Cayman
CAS:
126453-07-4
Storage:
-20
UN-No:
Non-Hazardous - /

(R)-CPP is an NMDA receptor antagonist (Ki = 0.14 µM).{51092} It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with Ki values of 0.04, 0.3, 0.6, and 2 µM, respectively.{51093} It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2).{51092} (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 µmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 µmol/kg).{51094}  

 

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Description

An NMDA receptor antagonist (Ki = 0.14 µM); binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits (Kis = 0.04, 0.3, 0.6, and 2 µM, respectively); inhibits NMDA-induced depolarizations in isolated hemisected frog spinal cord (pA2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA2 = 6.2); inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED50 = 65.8 µmol/kg) and the myoclonic phase of stroboscopic-induced seizures in P. papio photosensitive baboons (ED50 = 127 µmol/kg)

Formal name: (2R)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Synonyms: 

Molecular weight: 252.2

CAS: 126453-07-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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